General Information of the Compound
Compound ID
CP0914952
Compound Name
endo-2-(8-(bis(2-chlorophenyl)methyl)-3-carbamoyl-8-azabicyclo[3.2.1]octan-3-yl)-5-fluoroisonicotinic acid
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Formula
C27H24Cl2FN3O3
Molecular Weight
528.411
Canonical SMILES
NC(=O)[C@]1(c2cc(C(=O)O)c(F)cn2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
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InChI
InChI=1S/C27H24Cl2FN3O3/c28-20-7-3-1-5-17(20)24(18-6-2-4-8-21(18)29)33-15-9-10-16(33)13-27(12-15,26(31)36)23-11-19(25(34)35)22(30)14-32-23/h1-8,11,14-16,24H,9-10,12-13H2,(H2,31,36)(H,34,35)/t15-,16+,27-
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InChIKey
BZDGXSLJPOLSJO-BJFLIPCPSA-N
Physicochemical Property
logP
5.3652
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
96.52
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3084546
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 1000 nM
   TI
   LI
   LO
   TS