General Information of the Compound
Compound ID
CP0859605
Compound Name
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(4-methoxyphenyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide
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Formula
C30H32Cl2N2O2
Molecular Weight
523.504
Canonical SMILES
COc1ccc([C@]2(CNC(C)=O)C[C@H]3CC[C@@H](C2)N3C(c2ccccc2Cl)c2ccccc2Cl)cc1
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InChI
InChI=1S/C30H32Cl2N2O2/c1-20(35)33-19-30(21-11-15-24(36-2)16-12-21)17-22-13-14-23(18-30)34(22)29(25-7-3-5-9-27(25)31)26-8-4-6-10-28(26)32/h3-12,15-16,22-23,29H,13-14,17-19H2,1-2H3,(H,33,35)/t22-,23+,30-
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InChIKey
WDMPXDREEFNEFP-SZUMIOBZSA-N
Physicochemical Property
logP
6.7923
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
41.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3349282
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2407 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 118 nM
   TI
   LI
   LO
   TS