General Information of the Compound
Compound ID
CP0543954
Compound Name
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
    Show/Hide
Structure
Formula
C67H104N22O16
Molecular Weight
1473.707
Canonical SMILES
COc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)cc1
    Show/Hide
InChI
InChI=1S/C67H104N22O16/c1-38(81-54(93)36-80-60(99)50(33-42-21-25-44(105-3)26-22-42)88-64(103)51(32-40-13-5-4-6-14-40)83-55(94)35-78-53(92)34-79-59(98)45(70)31-41-19-23-43(91)24-20-41)57(96)85-49(18-12-30-77-67(74)75)62(101)87-47(16-8-10-28-69)63(102)89-52(37-90)65(104)82-39(2)58(97)86-48(17-11-29-76-66(72)73)61(100)84-46(56(71)95)15-7-9-27-68/h4-6,13-14,19-26,38-39,45-52,90-91H,7-12,15-18,27-37,68-70H2,1-3H3,(H2,71,95)(H,78,92)(H,79,98)(H,80,99)(H,81,93)(H,82,104)(H,83,94)(H,84,100)(H,85,96)(H,86,97)(H,87,101)(H,88,103)(H,89,102)(H4,72,73,76)(H4,74,75,77)/t38-,39-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1
    Show/Hide
InChIKey
SMEFOBTUNWHHRZ-VUCGMCGPSA-N
Physicochemical Property
logP
-7.23026
Rotatable Bonds
49
Heavy Atom Count
105
Polar Areas
643.84
Hydrogen Bond Donor Count
24
Hydrogen Bond Acceptor Count
21
Complexity
105

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 166631671
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 13.18 nM
   TI
   LI
   LO
   TS