General Information of the Compound
Compound ID
CP0427035
Compound Name
(1S,3R)-N-((5-(4-chlorophenyl)-1-isopropyl-4-(2-methoxyethyl)-1H-imidazol-2-yl)methyl)-3-fluorocyclopentanamine
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Structure
Formula
C21H29ClFN3O
Molecular Weight
393.934
Canonical SMILES
COCCc1nc(CN[C@H]2CC[C@@H](F)C2)n(C(C)C)c1-c1ccc(Cl)cc1
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InChI
InChI=1S/C21H29ClFN3O/c1-14(2)26-20(13-24-18-9-8-17(23)12-18)25-19(10-11-27-3)21(26)15-4-6-16(22)7-5-15/h4-7,14,17-18,24H,8-13H2,1-3H3/t17-,18+/m1/s1
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InChIKey
ZTCQDGJUOYNCFZ-MSOLQXFVSA-N
Physicochemical Property
logP
4.9535
Rotatable Bonds
8
Heavy Atom Count
27
Polar Areas
39.08
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44517710
SID: 85852934
ChEMBL ID
CHEMBL563593
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 5.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 7.6 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 16000 nM
   TI
   LI
   LO
   TS