General Information of the Compound
Compound ID
CP0920160
Compound Name
endo-8-(bis(2-chlorophenyl)methyl)-3-(5-methylpyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
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Formula
C27H27Cl2N3O
Molecular Weight
480.439
Canonical SMILES
Cc1ccc([C@@]2(C(N)=O)C[C@H]3CC[C@@H](C2)N3C(c2ccccc2Cl)c2ccccc2Cl)nc1
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InChI
InChI=1S/C27H27Cl2N3O/c1-17-10-13-24(31-16-17)27(26(30)33)14-18-11-12-19(15-27)32(18)25(20-6-2-4-8-22(20)28)21-7-3-5-9-23(21)29/h2-10,13,16,18-19,25H,11-12,14-15H2,1H3,(H2,30,33)/t18-,19+,27-
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InChIKey
DUVZMQWDCJPBLG-MZNYFNKISA-N
Physicochemical Property
logP
5.83632
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
59.22
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3084532
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 26 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6 nM
   TI
   LI
   LO
   TS