General Information of the Compound
Compound ID
CP0411391
Compound Name
1-(1-cyclooctylpiperidin-4-yl)-3-methyl-3H-indol-2-one
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Structure
Formula
C22H32N2O
Molecular Weight
340.511
Canonical SMILES
CC1C(=O)N(C2CCN(CC2)C2CCCCCCC2)c2ccccc12
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InChI
InChI=1S/C22H32N2O/c1-17-20-11-7-8-12-21(20)24(22(17)25)19-13-15-23(16-14-19)18-9-5-3-2-4-6-10-18/h7-8,11-12,17-19H,2-6,9-10,13-16H2,1H3
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InChIKey
YLJQVYWTNUVLEP-UHFFFAOYSA-N
Physicochemical Property
logP
4.714
Rotatable Bonds
2
Heavy Atom Count
25
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71624387
ChEMBL ID
CHEMBL2387195
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 < 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 39.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 94 nM
   TI
   LI
   LO
   TS
2
Ki = 10.49 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 30.2 nM
   TI
   LI
   LO
   TS
2
Ki = 12.65 nM
   TI
   LI
   LO
   TS