General Information of the Compound
Compound ID
CP0051361
Compound Name
1-(2-hydroxy-ethyl)-3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydrobenzimidazol-2-one
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Structure
Formula
C28H39N3O4
Molecular Weight
481.637
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CCO)c2=O)C(C)C)c1
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InChI
InChI=1S/C28H39N3O4/c1-20(2)26(35-27-19-23(34-4)10-9-21(27)3)13-16-29-14-11-22(12-15-29)31-25-8-6-5-7-24(25)30(17-18-32)28(31)33/h5-10,19-20,22,26,32H,11-18H2,1-4H3
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InChIKey
HMGPFWIOSDLAJS-UHFFFAOYSA-N
Physicochemical Property
logP
4.24292
Rotatable Bonds
10
Heavy Atom Count
35
Polar Areas
68.86
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437630
ChEMBL ID
CHEMBL391518
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 62 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 77 nM
   TI
   LI
   LO
   TS
2
Ki = 10 nM
   TI
   LI
   LO
   TS