General Information of the Compound
Compound ID
CP0496829
Compound Name
(2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-4-(4-methylphenyl)-4-oxobut-2-enamide
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Structure
Formula
C27H32N2O2
Molecular Weight
416.565
Canonical SMILES
Cc1ccc(cc1)C(=O)\C=C\C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
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InChI
InChI=1S/C27H32N2O2/c1-21-7-9-23(10-8-21)25(30)11-12-26(31)28-17-4-18-29-19-15-27(16-20-29)14-13-22-5-2-3-6-24(22)27/h2-3,5-12H,4,13-20H2,1H3,(H,28,31)/b12-11+
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InChIKey
STMKLDNLUFXSTR-VAWYXSNFSA-N
Physicochemical Property
logP
4.22022
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
49.41
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44406996
ChEMBL ID
CHEMBL202401
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
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   LI
   LO
   TS