General Information of the Compound
Compound ID
CP0145418
Compound Name
8-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
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Structure
Formula
C27H37N3O3
Molecular Weight
451.611
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC3(CC2)N(CNC3=O)c2ccccc2)C(C)C)c1
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InChI
InChI=1S/C27H37N3O3/c1-20(2)24(33-25-18-23(32-4)11-10-21(25)3)12-15-29-16-13-27(14-17-29)26(31)28-19-30(27)22-8-6-5-7-9-22/h5-11,18,20,24H,12-17,19H2,1-4H3,(H,28,31)
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InChIKey
RFAIVSNIWWKITN-UHFFFAOYSA-N
Physicochemical Property
logP
4.22562
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
54.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437654
ChEMBL ID
CHEMBL391650
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 34 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
2
Ki = 2 nM
   TI
   LI
   LO
   TS