General Information of the Compound
Compound ID
CP0449600
Compound Name
2-(1,3-benzothiazol-2-ylsulfanyl)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)acetamide
    Show/Hide
Structure
Formula
C25H29N3OS2
Molecular Weight
451.661
Canonical SMILES
O=C(CSc1nc2ccccc2s1)NCCCN1CCC2(CCc3ccccc23)CC1
    Show/Hide
InChI
InChI=1S/C25H29N3OS2/c29-23(18-30-24-27-21-8-3-4-9-22(21)31-24)26-14-5-15-28-16-12-25(13-17-28)11-10-19-6-1-2-7-20(19)25/h1-4,6-9H,5,10-18H2,(H,26,29)
    Show/Hide
InChIKey
UWZUEPMEMOCBRG-UHFFFAOYSA-N
Physicochemical Property
logP
4.8747
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
45.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44407086
ChEMBL ID
CHEMBL201826
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 290 nM
   TI
   LI
   LO
   TS