General Information of the Compound
Compound ID
CP0844203
Compound Name
Exo-8-[bis(2-chlorophenyl)methyl]-3-[3-bromo-2-pyridinyl]-8-azabicyclo[3.2.1]octane
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Formula
C25H23BrCl2N2
Molecular Weight
502.283
Canonical SMILES
Clc1ccccc1C(c1ccccc1Cl)N1[C@@H]2CC[C@H]1C[C@@H](c1ncccc1Br)C2
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InChI
InChI=1S/C25H23BrCl2N2/c26-21-8-5-13-29-24(21)16-14-17-11-12-18(15-16)30(17)25(19-6-1-3-9-22(19)27)20-7-2-4-10-23(20)28/h1-10,13,16-18,25H,11-12,14-15H2/t16-,17+,18-
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InChIKey
ADHVGVWDKXMVQG-BCDXTJNWSA-N
Physicochemical Property
logP
7.6509
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
16.13
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 85282689
ChEMBL ID
CHEMBL3084660
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8382 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 467 nM
   TI
   LI
   LO
   TS