General Information of the Compound
Compound ID
CP0904420
Compound Name
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(piperidin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
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Formula
C26H33Cl2N3
Molecular Weight
458.477
Canonical SMILES
NC[C@@]1(C2CCCCN2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
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InChI
InChI=1S/C26H33Cl2N3/c27-22-9-3-1-7-20(22)25(21-8-2-4-10-23(21)28)31-18-12-13-19(31)16-26(15-18,17-29)24-11-5-6-14-30-24/h1-4,7-10,18-19,24-25,30H,5-6,11-17,29H2/t18-,19+,24?,26-
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InChIKey
FKMZLMGCYLWSFS-QIORFDKFSA-N
Physicochemical Property
logP
5.7968
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
41.29
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3349253
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 17 nM
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