General Information of the Compound
Compound ID
CP0463344
Compound Name
2-{3-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-2,2-dioxo-2,3-dihydro-2lambda*6*-benzo[1,2,5]thiadiazol-1-yl}-N-methyl-acetamide
    Show/Hide
Structure
Formula
C23H36N4O3S
Molecular Weight
448.633
Canonical SMILES
CNC(=O)CN1c2ccccc2N(C2CCN(CC2)C2CCC(CC2)C(C)C)S1(=O)=O
    Show/Hide
InChI
InChI=1S/C23H36N4O3S/c1-17(2)18-8-10-19(11-9-18)25-14-12-20(13-15-25)27-22-7-5-4-6-21(22)26(31(27,29)30)16-23(28)24-3/h4-7,17-20H,8-16H2,1-3H3,(H,24,28)
    Show/Hide
InChIKey
DJCHJXJTDJZMOI-UHFFFAOYSA-N
Physicochemical Property
logP
2.983
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
72.96
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 46879539
ChEMBL ID
CHEMBL1076242
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 346 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
2
Ki = 6.4 nM
   TI
   LI
   LO
   TS