General Information of the Compound
Compound ID
CP0449595
Compound Name
3-phenoxy-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyridine-2-carboxamide
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Structure
Formula
C28H31N3O2
Molecular Weight
441.575
Canonical SMILES
O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ncccc1Oc1ccccc1
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InChI
InChI=1S/C28H31N3O2/c32-27(26-25(12-6-17-29-26)33-23-9-2-1-3-10-23)30-18-7-19-31-20-15-28(16-21-31)14-13-22-8-4-5-11-24(22)28/h1-6,8-12,17H,7,13-16,18-21H2,(H,30,32)
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InChIKey
ZEWITEBDAOYIQC-UHFFFAOYSA-N
Physicochemical Property
logP
4.9738
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
54.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407119
ChEMBL ID
CHEMBL202435
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
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