General Information of the Compound
Compound ID
CP0439566
Compound Name
8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamino)ethyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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Structure
Formula
C34H40Cl2N4O
Molecular Weight
591.627
Canonical SMILES
Clc1ccccc1C(N1CCC2(CC1)N(CN(CCNC1CCCCC1)C2=O)c1ccccc1)c1ccccc1Cl
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InChI
InChI=1S/C34H40Cl2N4O/c35-30-17-9-7-15-28(30)32(29-16-8-10-18-31(29)36)38-22-19-34(20-23-38)33(41)39(24-21-37-26-11-3-1-4-12-26)25-40(34)27-13-5-2-6-14-27/h2,5-10,13-18,26,32,37H,1,3-4,11-12,19-25H2
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InChIKey
PZRQTLDSILZECV-UHFFFAOYSA-N
Physicochemical Property
logP
7.146
Rotatable Bonds
8
Heavy Atom Count
41
Polar Areas
38.82
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25190589
ChEMBL ID
CHEMBL510745
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 759 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 224 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 400 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5 nM
   TI
   LI
   LO
   TS