General Information of the Compound
Compound ID
CP0530528
Compound Name
5-[4-(cyclooctylmethyl)piperazin-1-yl]-6-fluoro-2-[(4-fluorophenyl)methylsulfanyl]-1H-benzimidazole
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Structure
Formula
C27H34F2N4S
Molecular Weight
484.66
Canonical SMILES
Fc1ccc(CSc2nc3cc(F)c(cc3[nH]2)N2CCN(CC3CCCCCCC3)CC2)cc1
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InChI
InChI=1S/C27H34F2N4S/c28-22-10-8-21(9-11-22)19-34-27-30-24-16-23(29)26(17-25(24)31-27)33-14-12-32(13-15-33)18-20-6-4-2-1-3-5-7-20/h8-11,16-17,20H,1-7,12-15,18-19H2,(H,30,31)
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InChIKey
GJPKKBMGUAKZRZ-UHFFFAOYSA-N
Physicochemical Property
logP
6.6159
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
35.16
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44449823
ChEMBL ID
CHEMBL259066
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 10000 nM
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