General Information of the Compound
Compound ID
CP0406389
Compound Name
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-(4-methoxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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Structure
Formula
C62H102N22O16
Molecular Weight
1411.636
Canonical SMILES
COc1ccc(C[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O)cc1
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InChI
InChI=1S/C62H102N22O16/c1-34(76-48(88)32-75-60(99)50(36(3)86)84-58(97)45(29-38-20-22-39(100-4)23-21-38)78-49(89)31-73-47(87)30-74-54(93)40(65)28-37-14-6-5-7-15-37)52(91)80-44(19-13-27-72-62(69)70)56(95)82-42(17-9-11-25-64)57(96)83-46(33-85)59(98)77-35(2)53(92)81-43(18-12-26-71-61(67)68)55(94)79-41(51(66)90)16-8-10-24-63/h5-7,14-15,20-23,34-36,40-46,50,85-86H,8-13,16-19,24-33,63-65H2,1-4H3,(H2,66,90)(H,73,87)(H,74,93)(H,75,99)(H,76,88)(H,77,98)(H,78,89)(H,79,94)(H,80,91)(H,81,92)(H,82,95)(H,83,96)(H,84,97)(H4,67,68,71)(H4,69,70,72)/t34-,35-,36+,40-,41-,42-,43-,44-,45-,46-,50-/m0/s1
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InChIKey
OKPRQZQDCAIBAO-CXKFIQIKSA-N
Physicochemical Property
logP
-9.2171
Rotatable Bonds
48
Heavy Atom Count
100
Polar Areas
648.84
Hydrogen Bond Donor Count
22
Hydrogen Bond Acceptor Count
21
Complexity
100

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10986100
SID: 16043745
ChEMBL ID
CHEMBL415583
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 63.1 nM
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