General Information of the Compound
Compound ID
CP0499031
Compound Name
1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
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Structure
Formula
C27H34ClN3O2
Molecular Weight
468.041
Canonical SMILES
Cc1ccc(Cl)c(OC2(CCN3CCC(CC3)n3c4ccccc4[nH]c3=O)CCCCC2)c1
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InChI
InChI=1S/C27H34ClN3O2/c1-20-9-10-22(28)25(19-20)33-27(13-5-2-6-14-27)15-18-30-16-11-21(12-17-30)31-24-8-4-3-7-23(24)29-26(31)32/h3-4,7-10,19,21H,2,5-6,11-18H2,1H3,(H,29,32)
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InChIKey
MKACZIXYZBAILC-UHFFFAOYSA-N
Physicochemical Property
logP
6.10032
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
50.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44391012
ChEMBL ID
CHEMBL434150
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1115 nM
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