General Information of the Compound
Compound ID
CP0309394
Compound Name
1-ethoxymethyl-3-{1-[3-(5-methoxy-2-methylphenoxy)-4-methyl-pentyl]-piperidin-4-yl}-1,3-dihydrobenzimidazol-2-one
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Structure
Formula
C29H41N3O4
Molecular Weight
495.664
Canonical SMILES
CCOCn1c2ccccc2n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O
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InChI
InChI=1S/C29H41N3O4/c1-6-35-20-31-25-9-7-8-10-26(25)32(29(31)33)23-13-16-30(17-14-23)18-15-27(21(2)3)36-28-19-24(34-5)12-11-22(28)4/h7-12,19,21,23,27H,6,13-18,20H2,1-5H3
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InChIKey
HYIYVZGBQLFOJY-UHFFFAOYSA-N
Physicochemical Property
logP
5.24462
Rotatable Bonds
11
Heavy Atom Count
36
Polar Areas
57.86
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437604
ChEMBL ID
CHEMBL239045
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 9 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 92 nM
   TI
   LI
   LO
   TS
2
Ki = 5 nM
   TI
   LI
   LO
   TS