General Information of the Compound
Compound ID
CP0949689
Compound Name
(rel)-3-(4-fluorobenzyl)-8-(bis(2-chlorophenyl)methyl)-3-(pyrrolidin-1-ylmethyl)-8-aza-bicyclo[3.2.1]octane
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Formula
C32H35Cl2FN2
Molecular Weight
537.55
Canonical SMILES
Fc1ccc(C[C@]2(CN3CCCC3)C[C@H]3CC[C@@H](C2)N3C(c2ccccc2Cl)c2ccccc2Cl)cc1
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InChI
InChI=1S/C32H35Cl2FN2/c33-29-9-3-1-7-27(29)31(28-8-2-4-10-30(28)34)37-25-15-16-26(37)21-32(20-25,22-36-17-5-6-18-36)19-23-11-13-24(35)14-12-23/h1-4,7-14,25-26,31H,5-6,15-22H2/t25-,26+,32+
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InChIKey
TVEQTXYDMMDXJP-YHYNAULMSA-N
Physicochemical Property
logP
8.1736
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
6.48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3349262
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 58 nM
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