General Information of the Compound
Compound ID
CP0377406
Compound Name
methyl 2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetate
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Structure
Formula
C20H23NO3
Molecular Weight
325.408
Canonical SMILES
COC(=O)C(N1CCC(O)(CC1)c1ccccc1)c1ccccc1
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InChI
InChI=1S/C20H23NO3/c1-24-19(22)18(16-8-4-2-5-9-16)21-14-12-20(23,13-15-21)17-10-6-3-7-11-17/h2-11,18,23H,12-15H2,1H3
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InChIKey
QESUWOVHACTYFJ-UHFFFAOYSA-N
Physicochemical Property
logP
2.8843
Rotatable Bonds
4
Heavy Atom Count
24
Polar Areas
49.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44426818
ChEMBL ID
CHEMBL228736
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6753 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 59810 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1887 nM
   TI
   LI
   LO
   TS