General Information of the Compound
Compound ID
CP0374668
Compound Name
1-[1-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-piperidin-4-yl]-1,3-dihydro-indol-2-one
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Structure
Formula
C23H26N2O
Molecular Weight
346.474
Canonical SMILES
O=C1Cc2ccccc2N1C1CCN(CC1)C1CCCc2ccccc12
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InChI
InChI=1S/C23H26N2O/c26-23-16-18-7-2-4-10-21(18)25(23)19-12-14-24(15-13-19)22-11-5-8-17-6-1-3-9-20(17)22/h1-4,6-7,9-10,19,22H,5,8,11-16H2
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InChIKey
VCXYFBSSIJRBFS-UHFFFAOYSA-N
Physicochemical Property
logP
4.1177
Rotatable Bonds
2
Heavy Atom Count
26
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11371415
SID: 16464586
ChEMBL ID
CHEMBL101118
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 21.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 21.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 11.7 nM
   TI
   LI
   LO
   TS