General Information of the Compound
Compound ID
CP0375405
Compound Name
8-(bis(2-chlorophenyl)methyl)-3-(4-(trifluoromethoxy)phenyl)-8-azabicyclo[3.2.1]octane-3-carboxamide
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Structure
Formula
C28H25Cl2F3N2O2
Molecular Weight
549.42
Canonical SMILES
NC(=O)C1(CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ccc(OC(F)(F)F)cc1
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InChI
InChI=1S/C28H25Cl2F3N2O2/c29-23-7-3-1-5-21(23)25(22-6-2-4-8-24(22)30)35-18-11-12-19(35)16-27(15-18,26(34)36)17-9-13-20(14-10-17)37-28(31,32)33/h1-10,13-14,18-19,25H,11-12,15-16H2,(H2,34,36)
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InChIKey
RDTPBXFTWBKENH-UHFFFAOYSA-N
Physicochemical Property
logP
7.0315
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
55.56
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574851
ChEMBL ID
CHEMBL466469
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 285 nM
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