General Information of the Compound
Compound ID
CP0709541
Compound Name
8-(bis(2-chlorophenyl)methyl)-3-(5-bromopyridin-2-yl)-8-azabicyclo[3.2.1]octane-3-carboxamide
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Formula
C26H24BrCl2N3O
Molecular Weight
545.308
Canonical SMILES
NC(=O)[C@]1(c2ccc(Br)cn2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
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InChI
InChI=1S/C26H24BrCl2N3O/c27-16-9-12-23(31-15-16)26(25(30)33)13-17-10-11-18(14-26)32(17)24(19-5-1-3-7-21(19)28)20-6-2-4-8-22(20)29/h1-9,12,15,17-18,24H,10-11,13-14H2,(H2,30,33)/t17-,18+,26-
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InChIKey
IPZXKSGWFMKWBD-JSCPRHNGSA-N
Physicochemical Property
logP
6.2904
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
59.22
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL3084531
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 153 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 421 nM
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 29 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 63 nM