General Information of the Compound
Compound ID
CP0500669
Compound Name
3-[hydroxy(phenyl)methyl]-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)pyridine-2-carboxamide
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Structure
Formula
C29H33N3O2
Molecular Weight
455.602
Canonical SMILES
OC(c1ccccc1)c1cccnc1C(=O)NCCCN1CCC2(CCc3ccccc23)CC1
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InChI
InChI=1S/C29H33N3O2/c33-27(23-9-2-1-3-10-23)24-11-6-17-30-26(24)28(34)31-18-7-19-32-20-15-29(16-21-32)14-13-22-8-4-5-12-25(22)29/h1-6,8-12,17,27,33H,7,13-16,18-21H2,(H,31,34)
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InChIKey
SBEZGUMRMQPPQV-UHFFFAOYSA-N
Physicochemical Property
logP
4.2632
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
65.46
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407049
ChEMBL ID
CHEMBL201103
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 > 1000 nM
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