General Information of the Compound
Compound ID
CP0380886
Compound Name
3-ethyl-1-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]-3H-indol-2-one
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Structure
Formula
C24H28N2O
Molecular Weight
360.501
Canonical SMILES
CCC1C(=O)N(C2CCN(C\C=C\c3ccccc3)CC2)c2ccccc12
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InChI
InChI=1S/C24H28N2O/c1-2-21-22-12-6-7-13-23(22)26(24(21)27)20-14-17-25(18-15-20)16-8-11-19-9-4-3-5-10-19/h3-13,20-21H,2,14-18H2,1H3/b11-8+
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InChIKey
GFNNCQAQIGNTNV-DHZHZOJOSA-N
Physicochemical Property
logP
4.7046
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90655979
ChEMBL ID
CHEMBL3262552
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1367 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 = 2110 nM
   TI
   LI
   LO
   TS
2
Ki = 33.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS