General Information of the Compound
Compound ID
CP0112287
Compound Name
(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-acetic acid
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Structure
Formula
C28H37N3O5
Molecular Weight
495.62
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CC(O)=O)c2=O)C(C)C)c1
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InChI
InChI=1S/C28H37N3O5/c1-19(2)25(36-26-17-22(35-4)10-9-20(26)3)13-16-29-14-11-21(12-15-29)31-24-8-6-5-7-23(24)30(28(31)34)18-27(32)33/h5-10,17,19,21,25H,11-16,18H2,1-4H3,(H,32,33)
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InChIKey
IARHSJXOPBHUQS-UHFFFAOYSA-N
Physicochemical Property
logP
4.33522
Rotatable Bonds
10
Heavy Atom Count
36
Polar Areas
85.93
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437629
ChEMBL ID
CHEMBL238796
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 1701 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1595 nM
   TI
   LI
   LO
   TS