General Information of the Compound
Compound ID
CP0795317
Compound Name
Exo-8-[bis(2-chorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane
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Formula
C26H25Cl2N
Molecular Weight
422.399
Canonical SMILES
Clc1ccccc1C(c1ccccc1Cl)N1[C@@H]2CC[C@H]1C[C@@H](c1ccccc1)C2
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InChI
InChI=1S/C26H25Cl2N/c27-24-12-6-4-10-22(24)26(23-11-5-7-13-25(23)28)29-20-14-15-21(29)17-19(16-20)18-8-2-1-3-9-18/h1-13,19-21,26H,14-17H2/t19-,20+,21-
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InChIKey
ANZNNONCPKQWNN-WKCHPHFGSA-N
Physicochemical Property
logP
7.4934
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
3.24
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
SID: 85282831
ChEMBL ID
CHEMBL3084668
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 330 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 9 nM
   TI
   LI
   LO
   TS