General Information of the Compound
Compound ID
CP0435385
Compound Name
1-[1-(4,4-diphenylbutan-2-yl)piperidin-4-yl]-3-ethyl-3H-indol-2-one
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Structure
Formula
C31H36N2O
Molecular Weight
452.642
Canonical SMILES
CCC1C(=O)N(C2CCN(CC2)C(C)CC(c2ccccc2)c2ccccc2)c2ccccc12
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InChI
InChI=1S/C31H36N2O/c1-3-27-28-16-10-11-17-30(28)33(31(27)34)26-18-20-32(21-19-26)23(2)22-29(24-12-6-4-7-13-24)25-14-8-5-9-15-25/h4-17,23,26-27,29H,3,18-22H2,1-2H3
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InChIKey
GUACBINATKIUOJ-UHFFFAOYSA-N
Physicochemical Property
logP
6.6019
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90655977
ChEMBL ID
CHEMBL3262550
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4171 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 100 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS