General Information of the Compound
Compound ID
CP0461515
Compound Name
8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(2-oxopropyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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Structure
Formula
C28H35N3O2
Molecular Weight
445.607
Canonical SMILES
CC(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C2CCC(C)(C)c3ccccc23)C1=O
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InChI
InChI=1S/C28H35N3O2/c1-21(32)19-30-20-31(22-9-5-4-6-10-22)28(26(30)33)15-17-29(18-16-28)25-13-14-27(2,3)24-12-8-7-11-23(24)25/h4-12,25H,13-20H2,1-3H3
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InChIKey
SFJKZKRGYFETAG-UHFFFAOYSA-N
Physicochemical Property
logP
4.529
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
43.86
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25190608
ChEMBL ID
CHEMBL511649
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 795 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 56 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.5 nM
   TI
   LI
   LO
   TS