General Information of the Compound
Compound ID
CP0423620
Compound Name
8-((2-chloro-4-methylphenyl)(2-chlorophenyl)methyl)-3-((5-methoxypyridin-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-ol
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Structure
Formula
C28H30Cl2N2O2
Molecular Weight
497.466
Canonical SMILES
COc1ccc(CC2(O)CC3CCC(C2)N3C(c2ccccc2Cl)c2ccc(C)cc2Cl)nc1
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InChI
InChI=1S/C28H30Cl2N2O2/c1-18-7-12-24(26(30)13-18)27(23-5-3-4-6-25(23)29)32-20-9-10-21(32)16-28(33,15-20)14-19-8-11-22(34-2)17-31-19/h3-8,11-13,17,20-21,27,33H,9-10,14-16H2,1-2H3
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InChIKey
FCAIKVZTCKWJCO-UHFFFAOYSA-N
Physicochemical Property
logP
6.39542
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
45.59
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44574587
ChEMBL ID
CHEMBL466066
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 384 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 13 nM
   TI
   LI
   LO
   TS