General Information of the Compound
Compound ID
CP0449597
Compound Name
2-(3-phenoxyphenyl)-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)acetamide
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Structure
Formula
C30H34N2O2
Molecular Weight
454.614
Canonical SMILES
O=C(Cc1cccc(Oc2ccccc2)c1)NCCCN1CCC2(CCc3ccccc23)CC1
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InChI
InChI=1S/C30H34N2O2/c33-29(23-24-8-6-12-27(22-24)34-26-10-2-1-3-11-26)31-18-7-19-32-20-16-30(17-21-32)15-14-25-9-4-5-13-28(25)30/h1-6,8-13,22H,7,14-21,23H2,(H,31,33)
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InChIKey
ZFOFFMWZGSBBJE-UHFFFAOYSA-N
Physicochemical Property
logP
5.5077
Rotatable Bonds
8
Heavy Atom Count
34
Polar Areas
41.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44407112
ChEMBL ID
CHEMBL202091
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 340 nM
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