General Information of the Compound
Compound ID
CP0510865
Compound Name
(E)-3-phenyl-N-(3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropyl)prop-2-enamide
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Structure
Formula
C25H30N2O
Molecular Weight
374.528
Canonical SMILES
O=C(NCCCN1CCC2(CCc3ccccc23)CC1)\C=C\c1ccccc1
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InChI
InChI=1S/C25H30N2O/c28-24(12-11-21-7-2-1-3-8-21)26-17-6-18-27-19-15-25(16-20-27)14-13-22-9-4-5-10-23(22)25/h1-5,7-12H,6,13-20H2,(H,26,28)/b12-11+
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InChIKey
QITHKMFBAHBZTH-VAWYXSNFSA-N
Physicochemical Property
logP
4.1861
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
32.34
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11559820
SID: 16662088
ChEMBL ID
CHEMBL425225
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 540 nM
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