General Information of the Compound
Compound ID
CP0549304
Compound Name
1-[2-[8-(dimethylamino)-8-phenyl-2-azaspiro[4.5]decan-2-yl]ethyl]cyclobutane-1-carbonitrile
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Structure
Formula
C24H35N3
Molecular Weight
365.565
Canonical SMILES
CN(C)C1(CCC2(CCN(CCC3(CCC3)C#N)C2)CC1)c1ccccc1
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InChI
InChI=1S/C24H35N3/c1-26(2)24(21-7-4-3-5-8-21)13-11-23(12-14-24)16-18-27(20-23)17-15-22(19-25)9-6-10-22/h3-5,7-8H,6,9-18,20H2,1-2H3
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InChIKey
WDSLYWQYIJTXKC-UHFFFAOYSA-N
Physicochemical Property
logP
4.79358
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
30.27
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118662456
ChEMBL ID
CHEMBL4517646
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.5 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2.3 nM
   TI
   LI
   LO
   TS