General Information of the Compound
Compound ID
CP0460621
Compound Name
2-butyl-8-(dimethylamino)-8-thiophen-2-yl-2-azaspiro[4.5]decan-1-one
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Structure
Formula
C19H30N2OS
Molecular Weight
334.529
Canonical SMILES
CCCCN1CCC2(CCC(CC2)(N(C)C)c2cccs2)C1=O
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InChI
InChI=1S/C19H30N2OS/c1-4-5-13-21-14-12-18(17(21)22)8-10-19(11-9-18,20(2)3)16-7-6-15-23-16/h6-7,15H,4-5,8-14H2,1-3H3
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InChIKey
PLYOHNHGRVMVDF-UHFFFAOYSA-N
Physicochemical Property
logP
4.0978
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118662183
ChEMBL ID
CHEMBL4466714
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 170 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 600 nM
   TI
   LI
   LO
   TS