General Information of the Compound
Compound ID
CP0497282
Compound Name
2-(1'-(4-isopropylcyclohexyl)-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide
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Structure
Formula
C24H35N3O3
Molecular Weight
413.562
Canonical SMILES
CNC(=O)CN1C(=O)OC2(CCN(CC2)C2CCC(CC2)C(C)C)c2ccccc12
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InChI
InChI=1S/C24H35N3O3/c1-17(2)18-8-10-19(11-9-18)26-14-12-24(13-15-26)20-6-4-5-7-21(20)27(23(29)30-24)16-22(28)25-3/h4-7,17-19H,8-16H2,1-3H3,(H,25,28)
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InChIKey
XSGGRILSKJJOSZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.8951
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
61.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46879478
ChEMBL ID
CHEMBL1076208
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 108 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 448 nM
   TI
   LI
   LO
   TS
2
Ki = 106 nM
   TI
   LI
   LO
   TS