General Information of the Compound
Compound ID
CP0420149
Compound Name
1-(1-{2-[1-(2-Chloro-5-methyl-phenoxy)-cyclohexyl]-2-hydroxy-ethyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one
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Structure
Formula
C27H34ClN3O3
Molecular Weight
484.04
Canonical SMILES
Cc1ccc(Cl)c(OC2(CCCCC2)C(O)CN2CCC(CC2)n2c3ccccc3[nH]c2=O)c1
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InChI
InChI=1S/C27H34ClN3O3/c1-19-9-10-21(28)24(17-19)34-27(13-5-2-6-14-27)25(32)18-30-15-11-20(12-16-30)31-23-8-4-3-7-22(23)29-26(31)33/h3-4,7-10,17,20,25,32H,2,5-6,11-16,18H2,1H3,(H,29,33)
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InChIKey
YHSQFQMXFCKVHU-UHFFFAOYSA-N
Physicochemical Property
logP
5.07112
Rotatable Bonds
6
Heavy Atom Count
34
Polar Areas
70.49
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44390989
ChEMBL ID
CHEMBL424971
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 58 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 957 nM
   TI
   LI
   LO
   TS
2
Ki = 12 nM
   TI
   LI
   LO
   TS