General Information of the Compound
Compound ID
CP0221376
Compound Name
1-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methylpentyl]-piperidin-4-yl}-3-(2-methylamino-ethyl)-1,3-dihydro-benzimidazol-2-one
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Structure
Formula
C29H42N4O3
Molecular Weight
494.68
Canonical SMILES
CNCCn1c2ccccc2n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O
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InChI
InChI=1S/C29H42N4O3/c1-21(2)27(36-28-20-24(35-5)11-10-22(28)3)14-18-31-16-12-23(13-17-31)33-26-9-7-6-8-25(26)32(29(33)34)19-15-30-4/h6-11,20-21,23,27,30H,12-19H2,1-5H3
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InChIKey
LLYKNZRBKQHMCX-UHFFFAOYSA-N
Physicochemical Property
logP
4.47002
Rotatable Bonds
11
Heavy Atom Count
36
Polar Areas
60.66
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437638
ChEMBL ID
CHEMBL240084
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 46 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 99 nM
   TI
   LI
   LO
   TS
2
Ki = 2 nM
   TI
   LI
   LO
   TS