General Information of the Compound
Compound ID
CP0506549
Compound Name
N-methyl-2-[3-[1-(naphthalen-1-ylmethyl)piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
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Structure
Formula
C26H28N4O2
Molecular Weight
428.536
Canonical SMILES
CNC(=O)Cn1c2ccccc2n(C2CCN(Cc3cccc4ccccc34)CC2)c1=O
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InChI
InChI=1S/C26H28N4O2/c1-27-25(31)18-29-23-11-4-5-12-24(23)30(26(29)32)21-13-15-28(16-14-21)17-20-9-6-8-19-7-2-3-10-22(19)20/h2-12,21H,13-18H2,1H3,(H,27,31)
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InChIKey
WRAWHGUNWYZFJF-UHFFFAOYSA-N
Physicochemical Property
logP
3.5393
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
59.27
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46880237
ChEMBL ID
CHEMBL1080507
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 67 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 29 nM
   TI
   LI
   LO
   TS