General Information of the Compound
Compound ID
CP0500259
Compound Name
2-(1'-cycloheptyl-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide
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Structure
Formula
C22H31N3O3
Molecular Weight
385.508
Canonical SMILES
CNC(=O)CN1C(=O)OC2(CCN(CC2)C2CCCCCC2)c2ccccc12
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InChI
InChI=1S/C22H31N3O3/c1-23-20(26)16-25-19-11-7-6-10-18(19)22(28-21(25)27)12-14-24(15-13-22)17-8-4-2-3-5-9-17/h6-7,10-11,17H,2-5,8-9,12-16H2,1H3,(H,23,26)
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InChIKey
VSWRFLHZJLIZDC-UHFFFAOYSA-N
Physicochemical Property
logP
3.4031
Rotatable Bonds
3
Heavy Atom Count
28
Polar Areas
61.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46879627
ChEMBL ID
CHEMBL1081741
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 527 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2152 nM
   TI
   LI
   LO
   TS