General Information of the Compound
Compound ID
CP0399975
Compound Name
1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol
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Synonyms
1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol
CHEMBL234543
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Structure
Formula
C26H29NO
Molecular Weight
371.524
Canonical SMILES
CCc1ccc(cc1)C1(O)CCN(CC1)C(c1ccccc1)c1ccccc1
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InChI
InChI=1S/C26H29NO/c1-2-21-13-15-24(16-14-21)26(28)17-19-27(20-18-26)25(22-9-5-3-6-10-22)23-11-7-4-8-12-23/h3-16,25,28H,2,17-20H2,1H3
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InChIKey
JHTQREMVHFRWEJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.322
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
23.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44430012
ChEMBL ID
CHEMBL234543
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 24900 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 11355 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3433 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1281 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol )
Drug Name 1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol
Target(s)
Opioid receptor mu (MOP)
Inhibitor
Nociceptin receptor (OPRL1)
Inhibitor
Opioid receptor kappa (OPRK1)
Inhibitor