General Information of the Compound
Compound ID
CP0465214
Compound Name
1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1,3-dihydro-indol-2-one
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Structure
Formula
C28H28N2O
Molecular Weight
408.545
Canonical SMILES
CC(N1CCC(CC1)N1C(=O)Cc2ccccc12)c1ccc-2c(Cc3ccccc-23)c1
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InChI
InChI=1S/C28H28N2O/c1-19(20-10-11-26-23(16-20)17-21-6-2-4-8-25(21)26)29-14-12-24(13-15-29)30-27-9-5-3-7-22(27)18-28(30)31/h2-11,16,19,24H,12-15,17-18H2,1H3
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InChIKey
QPOLDKMLCWYJNP-UHFFFAOYSA-N
Physicochemical Property
logP
5.3725
Rotatable Bonds
3
Heavy Atom Count
31
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11165726
SID: 16245244
ChEMBL ID
CHEMBL328411
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 74.4 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 20.2 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 135 nM
   TI
   LI
   LO
   TS