General Information of the Compound
Compound ID
CP0221377
Compound Name
2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]ethyl acetate
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Structure
Formula
C30H41N3O5
Molecular Weight
523.674
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CCOC(C)=O)c2=O)C(C)C)c1
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InChI
InChI=1S/C30H41N3O5/c1-21(2)28(38-29-20-25(36-5)11-10-22(29)3)14-17-31-15-12-24(13-16-31)33-27-9-7-6-8-26(27)32(30(33)35)18-19-37-23(4)34/h6-11,20-21,24,28H,12-19H2,1-5H3
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InChIKey
LSLIXRZGWKCGHE-UHFFFAOYSA-N
Physicochemical Property
logP
4.81372
Rotatable Bonds
11
Heavy Atom Count
38
Polar Areas
74.93
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437617
ChEMBL ID
CHEMBL401248
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 103 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
2
Ki = 6 nM
   TI
   LI
   LO
   TS