General Information of the Compound
Compound ID
CP0371949
Compound Name
N-(cyclopropylmethyl)-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
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Structure
Formula
C32H44N4O4
Molecular Weight
548.728
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CC(=O)NCC3CC3)c2=O)C(C)C)c1
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InChI
InChI=1S/C32H44N4O4/c1-22(2)29(40-30-19-26(39-4)12-9-23(30)3)15-18-34-16-13-25(14-17-34)36-28-8-6-5-7-27(28)35(32(36)38)21-31(37)33-20-24-10-11-24/h5-9,12,19,22,24-25,29H,10-11,13-18,20-21H2,1-4H3,(H,33,37)
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InChIKey
BPTZNIFBGCSEMZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.77682
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
77.73
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437648
ChEMBL ID
CHEMBL393138
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 2034 nM
   TI
   LI
   LO
   TS
2
Ki = 12 nM
   TI
   LI
   LO
   TS