General Information of the Compound
Compound ID
CP0491851
Compound Name
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
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Structure
Formula
C22H26ClN3O2
Molecular Weight
399.922
Canonical SMILES
Cc1ccc(Cl)c(OCCCN2CCC(CC2)n2c3ccccc3[nH]c2=O)c1
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InChI
InChI=1S/C22H26ClN3O2/c1-16-7-8-18(23)21(15-16)28-14-4-11-25-12-9-17(10-13-25)26-20-6-3-2-5-19(20)24-22(26)27/h2-3,5-8,15,17H,4,9-14H2,1H3,(H,24,27)
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InChIKey
RLXSIHFFYALFRG-UHFFFAOYSA-N
Physicochemical Property
logP
4.39742
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
50.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44391023
ChEMBL ID
CHEMBL180402
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 410 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 282 nM
   TI
   LI
   LO
   TS