General Information of the Compound
Compound ID
CP0426817
Compound Name
(1S,2S,10R,18R)-19-(cyclopropylmethyl)-2,13-dihydroxy-8-(2-phenylethyl)-11-oxa-8,19-diazahexacyclo[10.9.1.01,10.02,18.04,9.016,22]docosa-4(9),12,14,16(22)-tetraen-7-one
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Structure
Formula
C31H34N2O4
Molecular Weight
498.623
Canonical SMILES
Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C1=C(CCC(=O)N1CCc1ccccc1)C[C@@]35O
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InChI
InChI=1S/C31H34N2O4/c34-23-10-8-21-16-24-31(36)17-22-9-11-25(35)33(14-12-19-4-2-1-3-5-19)27(22)29-30(31,26(21)28(23)37-29)13-15-32(24)18-20-6-7-20/h1-5,8,10,20,24,29,34,36H,6-7,9,11-18H2/t24-,29+,30+,31-/m1/s1
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InChIKey
OLGGVKYQNBLGAI-CTZUUEIXSA-N
Physicochemical Property
logP
3.6854
Rotatable Bonds
5
Heavy Atom Count
37
Polar Areas
73.24
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118705899
ChEMBL ID
CHEMBL3309516
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS