General Information of the Compound
Compound ID
CP0399718
Compound Name
N-(2-hydroxyethyl)-2-[3-[1-[3-(5-methoxy-2-methylphenoxy)-4-methylpentyl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]acetamide
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Structure
Formula
C30H42N4O5
Molecular Weight
538.689
Canonical SMILES
COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(CC(=O)NCCO)c2=O)C(C)C)c1
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InChI
InChI=1S/C30H42N4O5/c1-21(2)27(39-28-19-24(38-4)10-9-22(28)3)13-17-32-15-11-23(12-16-32)34-26-8-6-5-7-25(26)33(30(34)37)20-29(36)31-14-18-35/h5-10,19,21,23,27,35H,11-18,20H2,1-4H3,(H,31,36)
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InChIKey
JFBYKJVFAILWGC-UHFFFAOYSA-N
Physicochemical Property
logP
3.35912
Rotatable Bonds
12
Heavy Atom Count
39
Polar Areas
97.96
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44437644
ChEMBL ID
CHEMBL241155
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
Ki = 75 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 103 nM
   TI
   LI
   LO
   TS
2
Ki = 15 nM
   TI
   LI
   LO
   TS