General Information of the Compound
Compound ID
CP0883408
Compound Name
1-{1-[4-Methyl-3-(2-methyl-5-nitro-phenoxy)-pentyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
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Structure
Formula
C25H32N4O4
Molecular Weight
452.555
Canonical SMILES
Cc1ccc([N+](=O)[O-])cc1OC(CCN1CCC(n2c(O)nc3ccccc32)CC1)C(C)C
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InChI
InChI=1S/C25H32N4O4/c1-17(2)23(33-24-16-20(29(31)32)9-8-18(24)3)12-15-27-13-10-19(11-14-27)28-22-7-5-4-6-21(22)26-25(28)30/h4-9,16-17,19,23H,10-15H2,1-3H3,(H,26,30)
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InChIKey
JRFQTIHUIBASJA-UHFFFAOYSA-N
Physicochemical Property
logP
5.08912
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
93.66
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44391069
ChEMBL ID
CHEMBL180499
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 196 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 218 nM
   TI
   LI
   LO
   TS