General Information of the Compound
Compound ID
CP0437280
Compound Name
6-chloro-5-(4-ethylpiperazin-1-yl)-2-pentan-3-ylsulfanyl-1H-benzimidazole
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Structure
Formula
C18H27ClN4S
Molecular Weight
366.962
Canonical SMILES
CCC(CC)Sc1nc2cc(Cl)c(cc2[nH]1)N1CCN(CC)CC1
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InChI
InChI=1S/C18H27ClN4S/c1-4-13(5-2)24-18-20-15-11-14(19)17(12-16(15)21-18)23-9-7-22(6-3)8-10-23/h11-13H,4-10H2,1-3H3,(H,20,21)
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InChIKey
SFAFOFYAVJUENM-UHFFFAOYSA-N
Physicochemical Property
logP
4.6389
Rotatable Bonds
6
Heavy Atom Count
24
Polar Areas
35.16
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22272974
ChEMBL ID
CHEMBL263903
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 3.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 10 nM
   TI
   LI
   LO
   TS