General Information of the Compound
Compound ID
CP0949688
Compound Name
(rel)-1-((3-benzyl-8-(bis(2-chlorophenyl)methyl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)pyrrolidin-2-one
    Show/Hide
Formula
C32H34Cl2N2O
Molecular Weight
533.543
Canonical SMILES
O=C1CCCN1C[C@@]1(Cc2ccccc2)C[C@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl
    Show/Hide
InChI
InChI=1S/C32H34Cl2N2O/c33-28-13-6-4-11-26(28)31(27-12-5-7-14-29(27)34)36-24-16-17-25(36)21-32(20-24,19-23-9-2-1-3-10-23)22-35-18-8-15-30(35)37/h1-7,9-14,24-25,31H,8,15-22H2/t24-,25+,32+
    Show/Hide
InChIKey
OWKXLMNVGWQRGP-IXXHMTOTSA-N
Physicochemical Property
logP
7.5611
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
23.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL3349254
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 336 nM
   TI
   LI
   LO
   TS